RIBOSTAMYCIN SULFATE SALT
- Product Name
- RIBOSTAMYCIN SULFATE SALT
- CAS No.
- 25546-65-0
- Chemical Name
- RIBOSTAMYCIN SULFATE SALT
- Synonyms
- sf733;ribomycin;NSC 138925;vistamycin;dekamyciniv;hetangmycin;ribostamycin;antibioticsf733;RIBOSTAMYCIN SULPHATE;RIBOSTAMYCIN DISULFATE
- CBNumber
- CB1165751
- Molecular Formula
- C17H34N4O10
- Formula Weight
- 454.47
- MOL File
- 25546-65-0.mol
RIBOSTAMYCIN SULFATE SALT Property
- Melting point:
- 192-195°; mp 175-180° (dec)
- alpha
- D23 +42°
- Boiling point:
- 561.28°C (rough estimate)
- Density
- 1.1751 (rough estimate)
- refractive index
- 1.6700 (estimate)
- storage temp.
- 2-8°C
- pka
- 7.70(at 25℃)
Safety
- Hazard Codes
- T
- Risk Statements
- 61-20/21/22
- Safety Statements
- 53-22-36/37/39-45
- WGK Germany
- 3
- RTECS
- WK2300000
- Toxicity
- mouse,LD50,intracrebral,66800ug/kg (66.8mg/kg),BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLDLUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION,Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 2489, 1970.
N-Bromosuccinimide Price
- Product number
- 257381
- Product name
- Ribostamycin sulphate
- Packaging
- 100mg
- Price
- $446
- Updated
- 2021/12/16
- Product number
- 2844
- Product name
- Ribostamycin
- Packaging
- 10g
- Price
- $850
- Updated
- 2021/12/16
- Product number
- 2844
- Product name
- Ribostamycin
- Packaging
- 25mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 2844
- Product name
- Ribostamycin
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 2844
- Product name
- Ribostamycin
- Packaging
- 1g
- Price
- $235
- Updated
- 2021/12/16
RIBOSTAMYCIN SULFATE SALT Chemical Properties,Usage,Production
Description
Ribostamycin was found in the culture broth of Streptomyces ribosidificus by Meiji Seika Kaisha in 1970 in the course of screening aminoglycoside antibiotics. It is structurally related to neomycin but lacks the diaminoidose (glucose) moiety substituted on the ribose moiety. Ribostamycin is much less toxic than neomycin and shows strong activity against a variety of gram-positive and gram-negative bacteria, except Pseudomonas aeruginosa. It is used parenterally for therapy of urinary tract, respiratory tract, surgical, and other infections.
Definition
ChEBI: An amino cyclitol glycoside that is 4,6-diaminocyclohexane-1,2,3-triol having a 2,6-diamino-2,6-dideoxy-alpha-D-glucosyl residue attached at position 1 and a beta-D-ribosyl residue attache at position 2. It is an antibiotic produced by Streptomyces ribosidificus (formerly S. thermoflavus).
Mechanism of action
Ribostamycin (SF-733) is produced by Streptomyces ribosidificus. The free base is crystallized from methanol solution. The structure has been determined by chemical methods and total synthesis has been undertaken .